A high-fat diet and alcohol may lead to a harmful combination. A proposal in Am J Clin Nutr in 2006 proposed that cells containing extra fat made them more susceptible to lipid peroxidation. The hypothesis is because of a tie between elevated levels of the detox enzyme GGT and obesity. Elevated levels of GGT may be a compensatory factor. According to the study, obesity in animals and humans can accentuate alcohol-induced liver damage and cell injury.
Reference
http://www.ajcn.org/cgi/reprint/83/6/1351.pdf
